Wednesday, January 27, 2010

Immune Health and Cancer Prevention



As immune system function is intricately linked with both neurological and hormonal signalling and inflammation it should come as no surprise that scientific research is providing incontrovertible evidence regarding the importance of EPA and DHA Omega 3 fatty acids for healthy immune function and cancer prevention and survival/recovery. The research that EPA and DHA are essential for proper nerve signalling, hormonal production and regulation, immune function, and the regulation of inflammation is overwhelmingly conclusive.

Other likely physiological connections between EPA and DHA sufficiency and cancer prevention are the link between membrane fluidity, insulin resistance, and sex hormone binding globulins which are required to reduce the amount of free circulating hormones. An increase in free unbound circulating hormones is very highly correlated to an increase risk of cancer. Deficiency of EPA and DHA is linked with cell membrane rigidity which can cause insulin resistance. Insulin resistance causes a decrease in sex hormone binding globulin and an increase in circulating insulin both of which have been linked to significant increased cancer risk.

It is also significant that an increase in the ratio of Omega 6 to Omega 3 fatty acids has been shown to increase the risk of cancer. As previously mentioned, the average Western Diet is dangerously toxic with Omega 6 fatty acids and dangerously deficient in Omega 3 fatty acids, particularly EPA and DHA.
Supplementing with EPA and DHA from fish oil like Omega Sufficiency® has been shown to significantly reduce the risk of breast, colon, and prostate cancer and to decrease the rate of tumor growth in patients who have already developed cancer.

References

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Braden LM, Carroll KK. (1986). Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats. Lipids, vol. 21(4), p. 285-8.

Chages, V. and Bougnoux, P. Omega-6/omega-3 polyunsaturated fatty acid ratio and cancer. World Rev Nutr Diet. 2003; 92:133-51

Chung BH, Mitchell SH, et al., 2001. Effects of docosahexaenoic acid and eicosapentaenoic acid on androgen-mediated cell growth and gene expression in LNCaP prostate cancer cells. Carcinogenesis, Aug;22(8), p. 1201-6.

Connor, W.E. Importance of n-3 fatty acids in health and disease. Am J Clin Nutr, 2000 71(1): 171S-175S

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Gramaglia A, Loi GF, Mongioj V, Baronzio GF. Increased survival in brain metastatic patients treated with stereotactic radiotherapy, omega three fatty acids and bioflavonoids. Anticancer Res. 1999 Nov-Dec;19(6C):5583-6.

Kort WJ, Weijma IM, Bijma AM, van Schalkwijk WP, Vergroesen AJ, Westbroek DL. Omega-3 fatty acids inhibiting the growth of a transplantable rat mammary adenocarcinoma. J Natl Cancer Inst. 1987 Sep;79(3):593-9.

Maillard et al. N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France. Int. J Cancer 2002 Mar 1;98 (1): 78-83

Mukutmoni-Norris M, Hubbard NE, et al., 2000. Modulation of murine mammary tumor vasculature by dietary omega-3 fatty acids in fish oil. Cancer Lett, Mar 13;150(1):101-9.
Reddy, B.S. Omega-3 fatty acids in colorectal cancer prevention. Int J Cancer. 2004 Oct 20:112(1):1-7

Yam D, Peled A, Shinitzky M., (2001). Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin. Cancer Chemother Pharmacol, 47(1), p.34-40.

Yazawa, K. Importance of “health foods”, EPA and DHA, for preventive medicine. Rinsho Byori 2004 Mar; 52(3):249-53

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